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From: "George Irvine" <girvine@be*.ne*>
To: <jack@un*.co*>, <trey@ne*.co*>,
     "Esat Atikkan" , "Bruce R. Wienke" ,
     ,
Cc: "Quest@Gu*. Com" <quest@gu*.co*>
Subject: RE: FYI: RGBM WKPP/Irvine Test Deco Profile Comparison
Date: Wed, 13 Mar 2002 07:01:02 -0500

What part, mine or Esat's? Mine is easy - only a dumb fuck would jack up the
oxygen to think he is beating deco an take that degree of damage and
unacceptable risk. Esat's is easy also - the chemical description of what
you are doing to yourself by jacking the oxygen.

Ever feel that weird cramping discomfort in the big muscles on a dive? Esat
is describing that process in one sentence.

Esat is a scientist who is charged with finding causes, mechanisms and
possible cures for some of the most complex acting substances in this
universe. He has long ago learned not to draw conclusions without looking at
all the moving parts. He is the absolute best at seeing things that escape
the causal observer.

I merely iterate around until I find something that works, then I ask people
like Esat and Weinke why they think it works, thus raising my own
understanding and possibly seeing paths to the next level, so to speak.

-----Original Message-----
From: jack@un*.co* [mailto:jack@un*.co*]
Sent: Tuesday, March 12, 2002 10:37 PM
To: trey@ne*.co*; Esat Atikkan; Bruce R. Wienke;
deco@de*.or*; techdiver@aquanaut.com
Subject: RE: FYI: RGBM WKPP/Irvine Test Deco Profile Comparison


At the risk of sounding like a total moron (and getting flamed for it), can
someone translate this into something the layman can understand?

Thanks,

Jack



At 06:35 AM 3/12/02 -0500, George Irvine wrote:
>Esat, helium and very low PPO2s - I am diving in the .8 range.
>
>-----Original Message-----
>From: Esat Atikkan [mailto:atikkan@ya*.co*]
>Sent: Monday, March 11, 2002 9:23 PM
>To: Bruce R. Wienke; deco@de*.or*; techdiver@aquanaut.com
>Subject: Re: FYI: RGBM WKPP/Irvine Test Deco Profile Comparison
>
>
>
>The issue is nothing but having the biochem run
>following dives.  It would B best that it B run in the
>absence of DCS S&S as that would provide the baseline,
>& hopefully the abberation that leads to DCS would
>become evident.
>
>As for He, obviously good approach but still does not
>take peroxinitrates out of the picture as that lies in
>the cGMP/NO pathway that is thought to B central to
>the relaxation of vascular smooth muscle.
>
>There is no question that being in good cardiovascular
>& physical shape has benefits, but it is doubtful that
>it would afford protections against SOD depletion
>and/or peroxinitrates.
>
>Safe bubbles
>
>Esat Atikkan
>
>
>--- "Bruce R. Wienke" <brw@la*.go*> wrote:
> >   Yes.
> >
> >    Would be very interesting indeed -- this info
> > needs folding into
> >  diving on the envelope. Especially considering the
> > stress.
> >
> >     We take Vits. exercise, and are in great shape
> > here at/on
> >  LANL D-team, and will soon wet test 400/30 with He
> > on way up (not
> >  nitrox switches that George uses).  Our dives are
> > almost 90% He
> >  these days -- we avoid N2 as much as possible. We
> > are highly DCI absent
> >  on RGBM schedules.  Bottom line -- deep stops are
> > safe, cost effective,
> >  and time saving.  Even if "arbitrarily" built up
> > from Haldane.
> >
> >     Can't accurately quantify such complex
> > biochemistry, vascularity
> >  and related phenomenon, but such in coarse grain
> > deco planners enter thru
> > bub
> >  distribution, perfusion dilatation, etc., and
> > possibly oxygen sat.  If you
> >  have data linked to DCI, we might be able to say
> > something?
> >
> >
> >  BW
> >
> >
> >
> > >has anyone looked at hematological & bichemical
> > >parameters following these dives:
> > >Crit, [Hb], plasma osmolarity, RBC fragility come
> > to
> > >mind as do plasma volume changes.
> > >
> > >This would B fertile ground to assess the oxidative
> > >stress of such dives, wh/, over the long haul, may
> > B
> > >more significant than the putative bubble problems.
> > >
> > >I think Irvine & co deal w/ oxidative stress
> > through
> > >supplements of Vit E & C, wh/ would ameliorate the
> > SOD
> > >depletion, particularly the Cu/Zn SOD of the RBCs.
> > >
> > >However, the peroxinitrate relaxation mediated
> > >comprimise of vascular endothelial integrity does
> > come
> > >to mind as an area needing study.
> > >
> > >If I recollect correctly this was studied &
> > published
> > >(Undersea Hyperbar Med in the late 90's does come
> > to
> > >mind).  how it applies to the dives modelled here
> > >would be of interest.
> > >
> > >Safe bubbles
> > >
> > >Esat Atikkan
> > >
> > >__________________________________________________
> > >Do You Yahoo!?
> > >Try FREE Yahoo! Mail - the world's greatest free
> > email!
> > >http://mail.yahoo.com/
> >
> >
> >
>
>
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