At the risk of sounding like a total moron (and getting flamed for it), can 
someone translate this into something the layman can understand?

Thanks,

Jack



At 06:35 AM 3/12/02 -0500, George Irvine wrote:
>Esat, helium and very low PPO2s - I am diving in the .8 range.
>
>-----Original Message-----
>From: Esat Atikkan [mailto:atikkan@ya*.co*]
>Sent: Monday, March 11, 2002 9:23 PM
>To: Bruce R. Wienke; deco@de*.or*; techdiver@aquanaut.com
>Subject: Re: FYI: RGBM WKPP/Irvine Test Deco Profile Comparison
>
>
>
>The issue is nothing but having the biochem run
>following dives.  It would B best that it B run in the
>absence of DCS S&S as that would provide the baseline,
>& hopefully the abberation that leads to DCS would
>become evident.
>
>As for He, obviously good approach but still does not
>take peroxinitrates out of the picture as that lies in
>the cGMP/NO pathway that is thought to B central to
>the relaxation of vascular smooth muscle.
>
>There is no question that being in good cardiovascular
>& physical shape has benefits, but it is doubtful that
>it would afford protections against SOD depletion
>and/or peroxinitrates.
>
>Safe bubbles
>
>Esat Atikkan
>
>
>--- "Bruce R. Wienke" <brw@la*.go*> wrote:
> >   Yes.
> >
> >    Would be very interesting indeed -- this info
> > needs folding into
> >  diving on the envelope. Especially considering the
> > stress.
> >
> >     We take Vits. exercise, and are in great shape
> > here at/on
> >  LANL D-team, and will soon wet test 400/30 with He
> > on way up (not
> >  nitrox switches that George uses).  Our dives are
> > almost 90% He
> >  these days -- we avoid N2 as much as possible. We
> > are highly DCI absent
> >  on RGBM schedules.  Bottom line -- deep stops are
> > safe, cost effective,
> >  and time saving.  Even if "arbitrarily" built up
> > from Haldane.
> >
> >     Can't accurately quantify such complex
> > biochemistry, vascularity
> >  and related phenomenon, but such in coarse grain
> > deco planners enter thru
> > bub
> >  distribution, perfusion dilatation, etc., and
> > possibly oxygen sat.  If you
> >  have data linked to DCI, we might be able to say
> > something?
> >
> >
> >  BW
> >
> >
> >
> > >has anyone looked at hematological & bichemical
> > >parameters following these dives:
> > >Crit, [Hb], plasma osmolarity, RBC fragility come
> > to
> > >mind as do plasma volume changes.
> > >
> > >This would B fertile ground to assess the oxidative
> > >stress of such dives, wh/, over the long haul, may
> > B
> > >more significant than the putative bubble problems.
> > >
> > >I think Irvine & co deal w/ oxidative stress
> > through
> > >supplements of Vit E & C, wh/ would ameliorate the
> > SOD
> > >depletion, particularly the Cu/Zn SOD of the RBCs.
> > >
> > >However, the peroxinitrate relaxation mediated
> > >comprimise of vascular endothelial integrity does
> > come
> > >to mind as an area needing study.
> > >
> > >If I recollect correctly this was studied &
> > published
> > >(Undersea Hyperbar Med in the late 90's does come
> > to
> > >mind).  how it applies to the dives modelled here
> > >would be of interest.
> > >
> > >Safe bubbles
> > >
> > >Esat Atikkan
> > >
> > >__________________________________________________
> > >Do You Yahoo!?
> > >Try FREE Yahoo! Mail - the world's greatest free
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> >
> >
> >
>
>
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