It would probably be a very bad idea to try to build up any form of resistance/immunity to narcosis using nitrous oxide. Firstly the mechanism by which they work is different even though the effects are similair. Nitrous oxide works by inhibiting the enzyme methionine synthase (at least this is one of the effects it has). The end result of this is depletion of the levels of methionine in the body. This leads to megaloblastic anaemia as well as problems associated with brain function (memory deficits, demylenation to name but a few). On top of that it is addictive. So my advice is don't!!! John Gibbons School of Pharmacy Univ. London m
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