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To: jgibbo@cl*.ul*.ac*.uk*
To: techdiver@opal.com
Subject: Re: acclim. to narcosis using nitrous oxide
From: <Norm_Donkersloot@cc*.or*.mm*.co*>
Date: Fri, 24 Feb 1995 08:48 -0400 (EDT)
>It would probably be a very bad idea to try to build up any form of
>resistance/immunity to narcosis using nitrous oxide. Firstly the mechanism by
>which they work is different even though the effects are similair. Nitrous
>oxide works by inhibiting the enzyme methionine synthase (at least this is
>one of the effects it has). The end result of this is depletion of the levels
>of methionine in the body. This leads to megaloblastic anaemia as well as
>problems associated with brain function (memory deficits, demylenation to
>name but a few). On top of that it is addictive. So my advice is don't!!!

>John Gibbons
>School of Pharmacy
>Univ. London
============================================================================
It probably is not good for you but might be pleasant. Could you define
the enzyme methionine, it's use by the body, and megaloblastic please.
I get the impression of extreme anaemia ok, but since we are not all
chemists or doctors it might be helpful.
Thanks
Norm_Donkersloot@cc*.or*.mm*.co*

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