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Had some problem with first post, here's a repeat.
Have recently attended a presentation on the above by a
Prof Halliwell. I would like to run it and related queries,=20
by the list for opinions. Superoxide anion damage to DNA
was tracked by tracing 8OH deoxy Guanine, in urine.
=20
1 Subjects were given a commercially available antioxidant,
8OH dG was found in increased levels and study terminated
at 2 weeks.
=20
2 Same set of subjects were given 500gm of raw tomatoes,
{once a day} 8OH dG levels decreased and leveled off. Study terminated.
=20
3 When asked, he said that persons exposed to hyperbaric
oxygen showed an initial increase in degradative products, but levels
gradually decreased to pre-exposure levels. Time line not
mentioned.
=20
Aside, my questions are:-
Commercially available preparations of SOD, Catalase and
Glutathione Peroxidase don't make it the cellular level because
of protease action and stomach pH, and are therefore not worth
crap?
=20
If I'm planning preventive anti-ox therapy of vit E, C, Selenium etc
do I plan according to Ox Tox % per dive day or cumulative ox tox
per dive mission, or should I just go mega dose or saturation?
=20
Any feedback on pine bark extract?
=20
Omar
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<DIV><FONT color=3D#000000 size=3D2>Had some problem with first post, =
here's a=20
repeat.</FONT></DIV>
<DIV><FONT color=3D#000000 size=3D2></FONT> </DIV>
<DIV><FONT color=3D#000000 size=3D2>
<DIV>
<DIV><FONT color=3D#000000 size=3D2>Have recently attended a =
presentation on the=20
above by a</FONT></DIV>
<DIV><FONT color=3D#000000 size=3D2>Prof Halliwell. I would like to run =
it and=20
related queries, </FONT></DIV>
<DIV><FONT color=3D#000000 size=3D2>by the list for opinions. Superoxide =
anion=20
damage to DNA</FONT></DIV>
<DIV><FONT color=3D#000000 size=3D2></FONT><FONT size=3D2>was
tracked by =
tracing 8OH=20
deoxy Guanine, in urine.</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>1 Subjects were given a =
commercially=20
available antioxidant,</FONT></DIV>
<DIV><FONT size=3D2>8OH dG was found in increased levels and study=20
terminated</FONT></DIV>
<DIV><FONT size=3D2>at 2 weeks.</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>2 Same set of subjects were given =
500gm of=20
raw tomatoes,</FONT></DIV>
<DIV><FONT size=3D2></FONT>{once a day} <FONT size=3D2>8OH dG
levels =
decreased and=20
leveled off. Study terminated.</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>3 When asked, he said that persons =
exposed=20
to hyperbaric</FONT></DIV>
<DIV><FONT size=3D2>oxygen showed an initial increase in degradative =
products, but=20
levels</FONT></DIV>
<DIV><FONT size=3D2>gradually decreased to pre-exposure levels. Time =
line=20
not</FONT></DIV>
<DIV><FONT size=3D2>mentioned.</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>Aside, my questions are:-</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>Commercially available preparations of SOD, Catalase =
and</FONT></DIV>
<DIV><FONT size=3D2>Glutathione Peroxidase don't make it the cellular =
level=20
because</FONT></DIV>
<DIV><FONT size=3D2>of protease action and stomach pH, and are therefore =
not=20
worth</FONT></DIV>
<DIV><FONT size=3D2>crap?</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>If I'm planning preventive anti-ox therapy of vit E, =
C,=20
Selenium etc</FONT></DIV>
<DIV><FONT size=3D2>do I plan according to Ox Tox % per dive day or =
cumulative ox=20
tox</FONT></DIV>
<DIV><FONT size=3D2>per dive mission, or should I just go mega dose or=20
saturation?</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT size=3D2>Any feedback on pine bark extract?</FONT></DIV>
<DIV><FONT size=3D2></FONT> </DIV>
<DIV><FONT
size=3D2>Omar</FONT></DIV></DIV></FONT></DIV></BODY></HTML>
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