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From: <kirvine@sa*.ne*>
Date: Sun, 26 Dec 1999 16:00:06 -0500
To: "Michael J. Black" <mjblackmd@ya*.co*>
CC: Aquanaut Mail <techdiver@aquanaut.com>
Subject: Re: N2 Tolerance - disagree
False conclusion - you need to add these words "if they stay at it for
three days before their dive" - not real life, Mike, unless you want to
carry a chanmber, get smoked up in the chamber on air for three days,
then do your dive, and then it is only , as you pooint out, subjective,
and as I keep harping over and over , that subjectivity is based on the
impaired brain, and that is why we think of it the way we do. Mike if
this were not true, NOBODY woud ever drive a car drunk - they would
decide not to do so.

Michael J. Black wrote:
> 
> --- PVanscoik@ao*.co* wrote:
> > Dr. Black,
> > i would love to see some real data - repeat hyperbaric chamber dives
> > on the same cohort & test scores. are we debating facts or opinions?
> 
> Peter,
> 
> Here's some real data, albeit a small study, from the Journal of
> Undersea and Hyperbaric Medicine 1995 Mar;22(1):41-9 Dissociation of
> the Behavioral and Subjective Components of Nitrogen Narcosis and Diver
> Adaptation, by Hamilton K, Laliberte MF, Fowler B (DCIEM):  Abstract:
> 
> We investigated adaptation to nitrogen narcosis by compressing 11 highly
> experienced divers in a hyperbaric chamber to the equivalent of 54.6
> meters of seawater once a day for 5 consecutive days.  The behavioral
> component of narcosis was assessed with a serial choice-reaction time
> (RT) task, and the subjective component with a global magnitude estimate.
> Supplementary magnitude estimates were obtained with adjectives describing
> work effectiveness and body sensations.  The results showed that there
> was no adaptation on the RT task, although learning was evident.  In
> contrast, the global estimate dissociated from RT and showed clear adap-
> tation by Day 3.  The work effectiveness adjectives followed RT and did
> not show adaptation.  Some body sensation adjectives showed clear
> adaptation, but others did not.  These results lead to the conclusion
> that the anecdotal reports of adaptation by divers can probably be
> attributed to the subjective rather than the behavioral component of
> narcosis.  Dissociation of these components suggests mediation by different
> brain mechanisms, and it is speculated that the gamma-aminobutyric acidA/
> benzodiazepine receptor complex, which has been implicated in both the
> anesthetic and anxiolytic properties of agents such as nitrous oxide,
> may be involved. (end)
> 
> In other words, there is some degree of adaptation to nitrogen narcosis.
> Divers think they're better after repeated exposures but that's about it.
> 
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