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Date: Sat, 25 Dec 1999 11:20:58 -0800 (PST)
From: "Michael J. Black" <mjblackmd@ya*.co*>
Subject: Re: N2 Tolerance - disagree
To: Aquanaut Mail <techdiver@aquanaut.com>
--- PVanscoik@ao*.co* wrote:
> Dr. Black,
> i would love to see some real data - repeat hyperbaric chamber dives
> on the same cohort & test scores. are we debating facts or opinions?

Peter,

Here's some real data, albeit a small study, from the Journal of
Undersea and Hyperbaric Medicine 1995 Mar;22(1):41-9 Dissociation of
the Behavioral and Subjective Components of Nitrogen Narcosis and Diver
Adaptation, by Hamilton K, Laliberte MF, Fowler B (DCIEM):  Abstract:

We investigated adaptation to nitrogen narcosis by compressing 11 highly
experienced divers in a hyperbaric chamber to the equivalent of 54.6
meters of seawater once a day for 5 consecutive days.  The behavioral
component of narcosis was assessed with a serial choice-reaction time
(RT) task, and the subjective component with a global magnitude estimate.
Supplementary magnitude estimates were obtained with adjectives describing
work effectiveness and body sensations.  The results showed that there
was no adaptation on the RT task, although learning was evident.  In
contrast, the global estimate dissociated from RT and showed clear adap-
tation by Day 3.  The work effectiveness adjectives followed RT and did
not show adaptation.  Some body sensation adjectives showed clear
adaptation, but others did not.  These results lead to the conclusion
that the anecdotal reports of adaptation by divers can probably be
attributed to the subjective rather than the behavioral component of
narcosis.  Dissociation of these components suggests mediation by different
brain mechanisms, and it is speculated that the gamma-aminobutyric acidA/
benzodiazepine receptor complex, which has been implicated in both the
anesthetic and anxiolytic properties of agents such as nitrous oxide,
may be involved. (end)

In other words, there is some degree of adaptation to nitrogen narcosis.
Divers think they're better after repeated exposures but that's about it.


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