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On Tue, 24 Sep 1996 23:42:43 -0700 (PDT), you wrote: >In the package inserts, headache is reported with most quinolones at least >at the 5% level. Seizures and other bad stuff are much more rare. One >thing to keep in mind: the confidence limits for one are five, whatever >the risk. So a 5% adverse effect rate is almost always true for any drug. ok Pete,thanks,this is more understandable.It appeared you were stating the incidence of the more serious side effects was 5%,and that did not jive with the figures I had;5% rate of ANY adverse effect is certainly possible and acceptable. It would certainly seem that doxycycline is a much better choice;the subjective info that's been related here seems to suggest that the photosensitivity issue is not a large problem,(and there seem to be well-recognized warning signs such as tingling of the hands & feet if it IS going to be a concern) and the mechanism of action is better understood.My info does relate that the incidence of G.I disturbance is high,perhaps as much as 39%,but that much of this can be alleviated by drinking plenty of water when taking the med.However,my info says that taking at bedtime seems to produce a higher rate of gastric distress,and recommends avoiding this dosage.Also,use of sunblocks seem to have only limited efficacy in preventing the photosensitivity;corticosteroids and/or antihistamines may be necessary in the case of a severe reaction. Hopefully,one of these days I'll be in a position to report on this first-hand,when i get to take MY trip to PNG ;) Take care, John L. Dunk Tallahassee,Fl. screwloose@ne*.co*
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