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John,
On Wed, 25 Sep 1996, Dunk, John wrote:
> Pete,what's your source for this 5% figure?
Title: Toxicity of quinolone antimicrobial agents.
Author: Takayama-S. Hirohashi-M. Kato-M. Shimada-H.
Source: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH,
(1995 May) vol. 45(1): 1-45
These data and these analyses discuss all quinolone antibiotics. Mefloquin
is only one member of this group of drugs, and taken as malaria
prophylaxis, is dosed only once a week. So the frequency of perceived
reactions (CNS or other) is small. Mefloquin is also used to treat the
hepatic phase of primaquin resistant vivax malaria and is given on a daily
basis. The reactions seen in this situation are more frequent than those
found with primaquin, a distant relative of the quinolone class of drugs.
As an aside, enoxacin a quinolone not much used in US has, perhaps, the
most notorious CNS side effect profile, giving especially accelerated
reactions - a big buzz? - with caffeine. For this reason, it was picked by
Brazilian doctors as the quinolone most likely to succeed.
In the package inserts, headache is reported with most quinolones at least
at the 5% level. Seizures and other bad stuff are much more rare. One
thing to keep in mind: the confidence limits for one are five, whatever
the risk. So a 5% adverse effect rate is almost always true for any drug.
regards,
*******************************************************************
* Peter Heseltine, M.D., F.A.C.P. *
* Professor of Medicine *
* University of Southern California LAC+USC Medical Center *
* Tel; 213/226-6705 1200 North State Street *
* Fax: 213/226-2479 Los Angeles, CA 90033-1084 *
* eml: heseltin@hs*.us*.ed* USA *
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