I came across a good book for those peole who really want to get down to the nuts and bolts of what oxygen does to mammalian organisms. This book is not for the faint hearted but does give a comprehensive account of what free radicals are involved in. Its title is: Free radicals in Biology and Medicine 2nd ed. 1989, published by Oxford University press, Author Halliwell and Gutteridge. It is now seven years out of date but would be good for those interested in O2 tox. It had a nice little section on the possible adverse effect of high concentrations of Vit C for those folks who like to overindulge. In the presence of H2O2 it can produce hydroxyl radicals via the Fenton reaction (depending on conc. and a few other factors)and can stimulate iron dependant peroxidation of lipids. Just thought someone might be interested. J Gibbo John M. Gibbons 0171-793-1101 Home Univ. London School of Pharmacy 0171-582-6561 Fax Dept. of Pharmaceutical Chemistry 0171-753-5800 Wk ex 4882 jgibbo@cl*.ul*.ac*.uk* or jgibbo@ul*.ac*.uk*
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