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To Esat Atikkan: Thanks for your comments on my message on the production of CO2 and its effects on the oxygen carrying capacity of blood. You were more complete than I was ( I completely forgot about pyruvate, time to reread my Stryer again before writing a message). What I wanted to find out is: if we have a raised ppO2 in the blood, will it affect the ability of RBC to convert CO2 to carbonic acid and so reduce the carrying capacity of CO2 by the blood allowing it to build up in the tissues. If we simplify the lot down to a basic equilibrium then, The increased concentration of O2 will drive the (1) (1) HbO2 + H+ ----> HHb + O2 the other way (it is an equilibrium after all) This will then drive (2) (2) H2CO3 ----> H+ + HCO3- the other way. Which will finally affect the equilibrium of carbonic anhydrase (3) (3)CO2 + H2O ----ca----> H3CO2 Now I do not have the equilibrium constants for all of these reactions but I bet someone would love to spend an afternoon calculating the effects of high ppO2 on them. This would explain a part of CO2 retention in tissues while breathing high ppO2 breathing mixtures. Is this just an oversimplification, or am I missing something. By the way sorry for spelling your name wrong, no offence intended. John Gibbons John M. Gibbons 0171-793-1101 Home Univ. London School of Pharmacy 0171-582-6561 Fax Dept. of Pharmaceutical Chemistry 0171-753-5800 Wk ex 4882 jgibbo@cl*.ul*.ac*.uk* or jgibbo@ul*.ac*.uk*
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