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Date: Tue, 3 Oct 1995 11:13:21 -0700
To: B.Pickering@le*.ac*.uk*
From: cherf@ci*.co* (Scott Cherf)
Subject: Re: Aspirin for Stupidity
Cc: techdiver@terra.net
At 9:40 AM 10/3/95, Bruce Pickering wrote:
>> From:          Roderick Farb <rfarb@em*.un*.ed*>
>
>> Yes. What is this with aspirin and narcosis? I've heard of two aspirins
>> and a coke before.
>>
>Well i cannot say about the coke, but i believe the theory behind the
>asprins is the same for reducing the risk of an MI. One half (?)
>asprin per day reduces the "stickeness" of platelets by being a
>prostaglandin inhibitor, stopping them acting as seeds for bubble
>formation.
>I don't know of any paper that supports this hypothesis though in
>stopping DCI.

O.k. I started this, I guess it's time to come out of the closet.

In chap. 7 of Bennet & Elliot's Physiology & Medicine of Diving (4th ed),
there's a discussion of two experiments (pp 185-186) performed in 1962
and 1970 respectively.  Both of the studies noted that aspirin (Acetylsalicylic
acid) reduced the voltage necessary to evoke a response in rats that
were exposed to high N2 partial pressures (1.22 ATA N2, 1.0 ATA O2 - '62
and 6.41 ATA N2, .9 ATA O2 - '70).  Reductions were apparently large
and significant.

At the end of the section (p 187), Bennet notes that 'there is still
no pharmacological method of preventing inert gas narcosis in man'.  My
question is 'why?'.  Have any more recent studies been performed on
humans, and if not, are there any anecdotal observations people might
like to share?

I will now return to the soundproof booth.

Scott.


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