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># I've forgotten who asked but someone did wonder about Seladane.  I'm pretty
># sure that it isn't actually a decongestant but is instead an antihistamine.  
>
>Yes, there are some concerns with Seldane and existing heart problems. I
>also heard of possible interaction of Seldane with some common antibiotics.

Topic: TERFENADINE
(c)1974-1994 Micromedex Inc.   Vol. 79 Expires 3/94
A.  CARDIOVASCULAR EFFECTS
     1.  Rare reports of severe cardiovascular effects have
         occurred with terfenadine; the effects have also been
         reported with first and other second generation
         antihistamines.  Reactions include QT INTERVAL
         PROLONGATION, VENTRICULAR TACHYCARDIA, TORSADE DE
         POINTES, VENTRICULAR FIBRILLATION, DEATH, CARDIAC
         ARREST, HYPOTENSION, PALPITATIONS, and SYNCOPE.
         Persons with impaired liver function or those receiving
         ketoconazole, itraconazole, troleandomycin, or
         erythromycin are at increased risk for developing
         cardiovascular effects at recommended doses of
         terfenadine.  Cardiovascular effects are also more
         likely in overdose situations (Prod Info Seldane(R),
         1992; Prod Info Sporanox(R), 1992; Anon, 1992).

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