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Date: Fri, 28 Jul 1995 09:11:05 -0400
To: techdiver@terra.net
From: cwsmitka@ft*.rs*.me*.um*.ed* (Curt W. Smitka)
Subject: Re: High PO2 exposures and Airbreaks

If memory serve me right (my paper are still packed from moving) we are
actually talking about three (3) types of effects from high PP02.

1.  Acute Pulmonary (Aveolar) Oxygen Toxicity
2.  Oxygen Toxicity
3.  Whole Body Oxygen Toxicity

Air breaks when breathing 100% O2 are predominantly to limit the potential
of acute pulmonary (aveolar) oxygen toxicity  which is characterized by
loss of aveolar function (toxicity damage to aveolar) without other
symptoms of general oxygen toxicity.  If memory sevres me correctly this is
principally a concern with high % O2 and increasing diluent gas % even with
high PPO2 decreases the risk which is why air breaks are not usually
included when using mixes with <80% O2.

Symptoms of oxygen toxicity as we normally consider it do not include acute
aveolar damage and produces sysmptoms more closely associated with the CNS.
Onset is generally attributed to exposure to high PP02 and time, and is
not related to the actual % O2 in the mix.

Whole body oxygen toxicity is a function of the cumulative exposure and
toxic effects of prolonged exposure to high PPO2.

Rich,
I have not seen any reports that indicate problems with oxygen toxicity or
acute pulmonary oxygen toxicity when using rebreathers with conservative
PPO2 set points (1.2-1.4).  You may want to determine the max % O2 your
breathing at shallow stops to evaulate your potential for acute pulmonary
toxicity and consider periodic changes in your PPO2 setpoint as you
mentioned.

I would be more concerned about your whole body oxygen toxicity exposure
which you indicated may exceed the recommended total exposure for a single
dive.  The frequency of these exposures may lead to cummulative damage that
the body is not able to repair between exposures.  CNS damage and loss of
andaveolar function can occur with excesses whole body O2 exposure and
would be my primary concern.

Thats my $0.02 from buried memory.
Curt

Curt W. Smitka                          Phone:  (313) 747-0252
Administrative Manager                  Fax:    (313) 936-8620
Reproductive Sciences Program           Email:  cwsmitka@um*.ed*
University of Michigan
11th Floor, 300 N. Ingalls Bldg.
Ann Arbor, MI 48109-0404


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