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From: <swanncruz@oc*.ne*.au*>
To: "George Irvine" <kirvine@sa*.ne*>, <techdiver@aquanaut.com>,
    
Subject: Red Blood Cell Rigidity
Date: Mon, 11 Feb 2002 17:33:19 +0930
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"High partial pressures of nitrogen cause the red cells to become rigid =
and
get hung up in capillaries or damage them. The response of the body to =
this
and the immune response tend to close off the area . Anyone ( but a dive
instructor) can see what that means for decompression."
Hi George & List,
As always, thanks for the info.
With respect to red cell rigidity with a high pp of N2, my knowledge of =
physiology has dulled somewhat over the years, but red cells do distort =
(squash) as they move through smaller capillaries, which would make the =
prospect of increased rigidity of the RBC quite alarming. That is, small =
capillaries are smaller than RBC. Hence, it could be that we see RBCs =
unable to pass and associated capillary rupture.
Do you think there is a threshold partial pressure where the effect of =
RBC rigidity becomes marked, or is there a linear change?
I would think there would be an age variable here as well.
If so, did this (theoretical) threshold partial pressure of N2 (causing =
BBC rigidity) influence the GUE recomended mixes?
I realize you are keeping the narcotic values at around or less than =
30m.
What I am getting at is a "threshold physiologically damaging pp of N2", =
as well as a narcotic level.
We seem to be able to quantify a narcotic value (=3Dlevel).
This is fascinating stuff, and would keep some PhD students going for =
years.
Regards,
Jeff the Darwinian.

I'm going to send this quick, B4 I confuse myself any =
further.............


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<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD>
<META content=3D"text/html; charset=3Diso-8859-1" =
http-equiv=3DContent-Type>
<META content=3D"MSHTML 5.00.2919.6307" name=3DGENERATOR>
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<BODY bgColor=3D#ffffff>
<DIV><FONT face=3DArial size=3D2>"High partial pressures of nitrogen =
cause the red=20
cells to become rigid and<BR>get hung up in capillaries or damage them. =
The=20
response of the body to this<BR>and the immune response tend to close =
off the=20
area . Anyone ( but a dive<BR>instructor) can see what that means for=20
decompression."</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>Hi George & List,<BR>As always, =
thanks for the=20
info.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>With respect to red cell rigidity with =
a high pp of=20
N2, my knowledge of physiology has dulled somewhat over the years, but =
red cells=20
do distort (squash) as they move through smaller capillaries, which =
would make=20
the prospect of increased rigidity of the RBC quite =
alarming.</FONT><FONT=20
face=3DArial size=3D2> That is, small capillaries are smaller than RBC. =
Hence, it=20
could be that we see RBCs unable to pass and associated capillary=20
rupture.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>Do you think there is a threshold =
partial pressure=20
where the effect of RBC rigidity becomes marked, or is there a linear=20
change?</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>I would think there would be an age =
variable here=20
as well.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>If so, did this (theoretical) threshold =
partial=20
pressure of N2 (causing BBC rigidity) influence the GUE recomended=20
mixes?</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>I realize you are keeping the narcotic =
values at=20
around or less than 30m.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>What I am getting at is a "threshold=20
physiologically damaging pp of N2", as well as a narcotic =
level.</FONT></DIV>
<DIV><FONT face=3DArial size=3D2>We seem to be able to quantify a =
narcotic value=20
(=3Dlevel).</FONT></DIV>
<DIV><FONT size=3D2><FONT face=3DArial>This is fascinating stuff, and =
would keep=20
some PhD students going for years.</FONT></FONT></DIV>
<DIV><FONT size=3D2><FONT
face=3DArial>Regards,</FONT></FONT></DIV>
<DIV><FONT size=3D2><FONT face=3DArial>Jeff the =
Darwinian.</FONT></FONT></DIV>
<DIV><FONT size=3D2><FONT
face=3DArial></FONT></FONT> </DIV>
<DIV><FONT size=3D2><FONT face=3DArial>I'm going to send this quick,
B4 =
I confuse=20
myself any
further.............<BR></DIV></FONT></FONT></BODY></HTML>

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