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Finding an adequate model to deal w/ DCS or DCI is frustrating to say teh least. Indeed some studies have shown blood chem changes, though the significance remained meagre. Same goes fro the immunological changes that Ward et al pushed for a # of year. The issue is a model that depends on bubbles being the etilogical agent. Yet no one has been able to show a causal relationship b/ bubbles & DCS. A dose-response relationship (applying the Koch principle) has been even more elusive. So it has been empirical - the bubble notion, coupled w/ HBO works, so lets keep 2 it. As for platelet aggregation & the use of anti-coagulants. Best I recall the jury is out. Theory does support the nifty picture of a N2 bubble w/ the hydrophobic ends of fatty A+ sticking in, their hyfrophilic ends out, representing foci for platelet aggregation - microthrombi @ work. But no one has conclusively shown them - I am willing to B corrected on this if there is evidence. Then again how does that extrapolate to DCS of He diving. So the issue remains - what does aspirin (salicyl acetate) do? Well aspirin is an analgesic. It does help w/ pain. DCS produces pain - hmmm! Hence the advise against aspirin in the context of diving - a pain killer takes away the primary diagnostic tool. Francis has held that DCS is really a very diffuse disease (Disseminated Vascular Disease as he calls it). This is a tidy definition because it covers all aspects of the etiology w/o committing itself to any specific measurable parameter - sort of the reason why an objective test for DCS has been so elusive. A threshold concept that models a # of the rheological changes may have to B invoked as CPK changes, Ig changes, platelet aggregation have all been reported - yet none has been significant enough to provide the diagnostic tool. U dives & U takes your chances - bubbles or no bubbles, platelet aggregation or no platelet aggregation, 5a up or down. Thus in thinking prophylaxis one has to 1st question what is really known about the mechanism/pathway by wh/ the protective agent could plausibly act on the etiology, where that also remains cloudy. Hey mayB we thnk science too much. Safe bubbles (whatever they R) Esat Atikkan > I'm not trying to rain on anyone's parade here, I'm > just trying to find out > what is actually KNOWN and not what is BELIEVED. > > Later, > > JoeL > > -- > Send mail for the `techdiver' mailing list to > `techdiver@aquanaut.com'. > Send subscribe/unsubscribe requests to `techdiver-request@aquanaut.com'. __________________________________________________ Do You Yahoo!? Send instant messages with Yahoo! Messenger. http://im.yahoo.com/ -- Send mail for the `techdiver' mailing list to `techdiver@aquanaut.com'. Send subscribe/unsubscribe requests to `techdiver-request@aquanaut.com'.
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