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At 02:36 PM 3/9/00 -0800, Michael J. Black wrote:

Hello Mike,

>Mike Rodriguez wrote:
>
>> Banks Anderson, an ophthalmologist, wrote in interesting paper on
>> the topic in which he describes the development of up to 1.6
>> diopters of myopia in people repeatedly exposed to a PO2 of 2.0.
>> Measurements of the curvature of the cornea revealed no change, so
>> it appears the hyperoxic myopia is caused by a metabolic change in
>> the lens which alters its refractive index.  Fortunately, Dr. Anderson
>> found that the myopia wears off after a few months and doesn't appear
>> to have any lasting effect.
>
>Have been gone for several days, attending an ophthalmology meeting
>in Philadelphia, and missed this thread.  Although I have not seen
>hyperoxic myopia clinically in my practice, the above statement appears
>correct, i.e. the myopic change is a metabolic effect on the human
>lens.  This is similar to the metabolic change that can develop in
>diabetic patients with fluctuating blood glucose levels.  The increase
>in blood glucose affects the sorbitol pathway into the lens, causing
>it to swell and change the refraction in a myopic direction.  The
>myopic changes in diabetics are more transient than the changes that
>develop in divers, although they both are reversible.  Can you cite a
>link for the paper you mentioned.  Hyperoxic myopia does not get very
>much attention in the ophthalmic literature.  MJB

Yup:

Anderson, B. Jr: Axial Length in Hyperoxic Myopia.
Underwater and Hyperbaric Physiology IX, eds. A. A. Bone, A.
J. Bachrach and L. J. Greenbaum, Jr., Bethesda, MD, pp. 607-611, 1987.

I have a paper copy, but I don't have a soft-copy or a link to
one.  Check with the publisher.

-Mike Rodriguez
<mikey@ma*.co*>
Pn(x) = (1/(2^n)n!)[d/dx]^n(x^2 - 1)^n

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