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David, Well, you don't like my hypothesis - can you come up with an alternative one or do you discount the anecdotal observations it attempted to address? #This is not so. There is little (or no?, comments Prime Ra?) evidence that #bubbles trap in the arterial circulation. One workers calculations suggest #that the bubble, which would be tubular in shape, would need to extend #through three generations of arteries before they would trap. Firstly, if bubbles were to lodge at all I would imagine them to do so in arterioles/capillaries: I didn't mean to imply they could get trapped in the arteries themselves. If this trapping can't happen, then how does the lung normally trap the so-called "silent bubbles" present in the pulmonary artery? Secondly, lack of evidence don't always mean something ain't true. #Bubbles are a problem if untrapped, they activate the complement and kinin #systems and damage the blood vessel endothelium. That's why I said simplistically, and I didn't suggest that bubble trapping was the only factor involved. Were your assertion correct, then why would arterial bubbles be considered more of a problem (PFO and the like) than venous ones per se? Are the complement and kinin systems only activated on the passage of bubbles through capillaries? Bob Talbot
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