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George,

  The example of pharmacologic management of intermittent claudication 
was in no way an endorsement for the use of pentoxyfylline by divers.  
This was put forth as a clinical evidence of the effects of RBC 
rigidity. The population who would use this medication are 
predominantly elderly and usually cannot exert themselves without 
experiencing muscle cramping and fatigue. I do realize that there are 
individuals that want to take the easy way out by "taking a pill". This 
drug has no place in technical diving. George, thanks for pointing out 
what the mindset of the tech diver should be.  
  The scenario of high ppN2 effecting the ability of RBC's to perform 
their "basic" function in the microcirculation should scare anyone away 
from deep air. 

Meade McCrory

Pharmacist/Dive Inst/Blue Hole dreamer

  
G. Irvine wrote:
> 
> This is why we do not dive air deep, and would explain the spinal and
> brain lesions, as well as the subclinical DCS symptoms following air
> dives beyond the usual zone. On the other hand , we don't experimant
> with powrful drugs under pressure, especially when conditioning and
> non-narcotic mixes will produce the same result. I realize that this is
> out of the question for some of the more vocal deep air promoters, but
> then this fits perfectly : it takes a lot of work to do real tech
> diving, and all it takes to deep air dive is stupidity and a place to
> jump in.
> 
> Meade McCrory wrote:
> >
> > Ben and others,
> >
> >   I think a more relevant discussion of high ppN2 and RBC rigidity
> > should include tissue oxygenation. The bi-concave shape of RBC's is
> > designed to allow the RBC to twist and deform to enter areas of the
> > microcirculation.There are pharmacologic means to enhance this ability
> > of the RBC's to perform this function eg.)pentoxifylline-to improve
> > oxygenation in a diagnosis of intermittent claudication.
> >   In my opinion this seems to be more important than it's possible
> > hypertensive effects.Has anyone looked at this before?
> >
> > Meade McCrory
> > Pharmacist/Dive Inst/Blue Hole dreamer
> >
> >
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