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Ben and others,

  I think a more relevant discussion of high ppN2 and RBC rigidity 
should include tissue oxygenation. The bi-concave shape of RBC's is 
designed to allow the RBC to twist and deform to enter areas of the
microcirculation.There are pharmacologic means to enhance this ability 
of the RBC's to perform this function eg.)pentoxifylline-to improve 
oxygenation in a diagnosis of intermittent claudication.
  In my opinion this seems to be more important than it's possible 
hypertensive effects.Has anyone looked at this before? 

Meade McCrory
Pharmacist/Dive Inst/Blue Hole dreamer


Ben Greenhouse wrote:
> 
> Nelson;
> 
>     "One" never claimed to be an expert, my rationale behind that
> thought was that the blood would become more viscous due to the
> increased rigidity of the RBCs.  This in turn would cause an elevation
> in blood pressure.  Sound fair to you?
> 
> Ben
> 
> nelson wrote:
> 
> > Ben Greenhouse wrote:
> > >
> > > Dave:
> > >
> > >     I'm not too sure of any longterm problems, but I would imagine
> that
> > > an immediate problem from
> > > red blood cell rigidity is hypertension.  The increased work your
> heart
> > > has to
> > > do in this situation may increase nitrogen uptake.  As well, the
> reduced
> > > blood
> > > flow in your circulatory system due to the hypertension may inhibit
> > > off-gassing from poorly circulated regions.  Anyone agree/disagree?
> > >
> > > Dave Nunes wrote:
> > >
> > > > Bill Mee wrote:
> > > > >
> > > > > From a strictly physiological viewpoint you will definitely feel
> 
> > > less
> > > > > tired and more "energetic" post dive following a lengthy
> exposure
> in
> > > the
> > > > > 100' range after breathing a gas mix where helium replaces part
> of
> > > the
> > > > > nitrogen. We know that red blood cells become rigid at high
> ppn2s
> > > and
> > > > > loose some of their hemodynamic characteristics which benefit
> plug
> > > > > capillary flow.  On the other hand helium is a "fast" highly
> mobile
> > > gas
> > > >
> > > > Bill,
> > > >
> > > > Please forgive my ignorance but, what are the
> > > (physiological??/Medical??)
> > > > side effects of red blood cells becoming rigid due to high ppn2's,
> 
> can
> > > this
> > > > cause any problems with normal everyday health (in the long or
> short
> > > term),
> > > > is it permanent damage? What does this do to one's body?
> > > >
> > > > Ciao
> > > >
> > > > Dave Nunes
> > > > Infoview Client systems
> > > >
> > > > --
> > > > Send mail for the `techdiver' mailing list to
> > > `techdiver@aquanaut.com'.
> > > > Send subscribe/unsubscribe requests to
> > > `techdiver-request@aquanaut.com'.
> 
> > What is the scientific rationale that increased RBC rigidity causes
> > hypertension?  That is the nice thing about science...it soon
> separates
> > the fact from the fiction or BS).  One would also question whether one
> 
> > has the education and background to make such statements.
> 
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