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To: jms@fe*.ed*.ac*.uk*
To: techdiver@opal.com
Subject: Re: tissue times
From: <JOHNCREA@de*.co*>
Date: Tue, 26 Jul 1994 06:31:30 -0400 (EDT)
Jason,

"Tissues" is a very poor term for use in describing theoretical 
compartments with a given halftime.  

However, due to the fact that these compartments are made up of
tissues (although these tissues are possibly scattered all over
the body), the term "tissues" has been used as a substitute 
for the more accurate "compartments".

Thus, in real life, there are very broad groupings of "tissues"
based on perfusion, and there are no real correlations between
a specific halftime (as the body autoregulates blood flow, and 
due to this, the halftime at any given site can vary, and especially
in the shorter halftime compartments can vary very significantly).

Roughly, the very short halftime "tissues" are blood, the heart, the brain,
and the kidneys.  The very long halftime compartments are the synovial
fluid in joints, bone, etc.

In between these extremes, there is no clean and clear goupings.  Muscle
can vary from a fairly short to a longer haltime based upon usage and
metabolic requirements.

Bottom line is that there are NO cut and dried answers to your question.

John
Submariner Research, Ltd.
(johncrea@op*.co*)

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