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>I am aware of anecdotal evidence for a link between >pseudoephedrine and O2 toxicity. If there is any empirical evidence I >would appreciate this information. Thanx, Pete Good to my threat, I just checked the Toxline database at NIH to see if there's any articles discussing any synergistic effects between sudafed and O2 toxicity...nada...nothing listed. That doesn't mean there's nothing out there, only not in the journals cataloged by the National Library of Medicine (which isn't everything). Their system only goes back to about 1966. The real problem with sudafed (or any antihistamine for that matter) and diving is that it wears off in a "hostile" environment leaving you worse off than if you were on the surface. If you follow my reasoning, people take antihistamines to help keep their sinuses and eustasian tubes open. Now take a diver with say just a low grade marginal head cold or just inflammation. He pops a sudafed and goes for a dive.(dumb move , but this is hypothetical after all) He's just open enough to partially clear, but as he is exposed to deeper, colder water, the eustasian tubes begin to reflexively shrink down from the cold (they can shrink closed by almost 2/3's I'm told by my diving med friends) from what they were on the surface. Now the drug is metabolizing and starts to wear off (possibly at a faster rate than the surface). What little clearing benefits there were are wearing off. By now the diver is at depth and pressurized. He's got to ascend sometime but now he's a set-up for a reverse squeeze since he's relatively overpressurized behind closed eustasian tubes. As if that's not bad enough, you want to throw in O2 toxicity for good measure?...You're a tough guy, Pete! ;-) Sorry the lit search wasn't more productive. Take care. Robb Wolov
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