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Date: Wed, 28 Feb 1996 13:01:07 -0500
To: Robert Wolov <wolov@hi*.co*>
From: dlv@ga*.ne* (Dan Volker)
Subject: Re: DAN Article
Cc: techdiver@terra.net
Robert,
I have to say that you are making some great contributions to this list. 
Please keep it up!

>>Robert
>>good response Can you provide me the paper reference on the cig vs 
>>altitude, that is excellent information.
>
>It was quite some time ago I came across that "tidbit". I believe it was 
>from either the Navy's Flight Surgeon Manual or the Aerospace 
>Physiologist's Manual. 
>What it was really refering to was the increased levels of carbon 
>monoxide in cigarette smoke. As most of you are aware, this bonds to the 
>hemoglobin in red cells irreversibly tying up receptor sites (normally 4 
>per hemoglobin molecule). Physiologically, since you have fewer available 
>sites, it looks to the body as if the air is "thinner" with less O2 
>available going into a normal number of hemoglobin-O2 pick-up sites (what 
>you really have is a normal concentration of O2 with a reduced number of 
>pick-up sites). It's a crude approximation, but "close enough for 
>government work". While I've not seen the Navy's undersea medicine manual 
>yet (that's next on my agenda) you're still tying up the same O2 
>receptors when you smoke and dive as when you smoke and fly...I can't see 
>how that's a good thing in either case. A red cell normal survives in the 
>body for about 
>120 days, so once you start to tie up receptor sites, the  effects hang 
>around a bit.
>
>We haven't even gotten into the physical effects on the lungs, like the 
>lose of the hair cells (cilia) that clean the debris out or the changes 
>in the cells ("dysplasias") and other "doc-speak" that means that the 
>cells start to look "funny" on their way to becoming cancerous (which is 
>decidedly *NOT FUNNY*). 
>
>>
>>Also, I like some others find it difficult to state someone is in good 
>>shape when they do not exercise. Having been involved in diving and 
>>exercising the majority of my life I discovered that to be in shape I 
>>had to workout.
>
>Aerobically conditioned people have more "efficient", toned 
>cardiovascular systems and O2 utilization. Just as a conditioned runner 
>may have a resting heart rate of say 47 compared to the typical person in 
>the 70's. They're more relaxed, they breath slower. They have a 
>physiologic reserve in the event they need to respond to a crisis. 
>
>My diving experience is so minimal at this stage of training, I shouldn't 
>comment further, but the above state of health sure sounds like an ideal 
>state of affairs at depth where you're trying to get the most "bang for 
>the buck" from a limited, finite air supply.
>
>>
>>Drugs and diving, we have a lot of information that reflects that 
>>decongestants such as sudafed may contribute to diving accidents, which 
>>we published three years ago. correct me if I'm wrong but drugs are 
>>effective by producing biochemical changes in the physiology, if this 
>>is true they have to effect divning safety one way or another. It would 
>>seem that unless a drug had a proven positive side effect on diving and 
>>diving related disorders that the RULE SHOULD BE DO NOT DIVE WHEN ON 
>>DRUGS AND MAEDICATIONS PERIOD. IF YOU NEED A DRUG FOR SOME REASON STAY 
>>DRY.
>
>I'm in absolute agreement. Keep in mind that I'm a pathologist and flight 
>surgeon, not a pharmacologist, so I can't speak to the individual 
>chemical reactions, but drugs react in unpredicable ways at altitude and 
>depth. I'm not sure whether its a change in the relative gas saturations 
>or what, but the fact is that an aviator at altitude or a diver at depth 
>is physiologically, "altered" temporarily from the same person at sea 
>level at one atmosphere and the usual gas partial pressures. Drug testing 
>usually takes place where everyone else lives (sea level in open air) not 
>where aviators and divers live. We give sudafed to aviators *under 
>supervision* since it has the least effect on motor-sensory activities at 
>altitude. But an aviator doesn't have to contend with the diver's N2 
>narcosis effects at depth (or O2 toxicity at even deeper depths). Might 
>there be a synergistic effect between such drugs and ppN2 narcosis? Might 
>be, but I wouldn't what to be the diver to personally find out! Ain't 
>worth it! (as a newbie "dry-behind-the-ears" diver I've heard the one 
>about the guy who tried to buddy breath with a grupper!)
>
>I'm personally increasing my excercise program since I took up diving to 
>shed a few more pounds if only to hold on to less N2 and carry less lead! 
>(the additional conditioning reserve wouldn't hurt either)
>
>Take care.
>
>Robb Wolov 
>
>--
>Send mail for the `techdiver' mailing list to `techdiver@terra.net'.
>Send subscription/archive requests to `techdiver-request@terra.net'.
>
>
Dan Volker
SOUTH FLORIDA DIVE JOURNAL
"The Internet magazine for Underwater Photography and mpeg Video"
http://www.florida.net/scuba/dive
407-683-3592

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