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From: <BrianE@an*.an*.ui*.ed*>
To: techdiver@terra.net, BrianE@an*.an*.ui*.ed*
Date: Wed, 11 Oct 95 15:29 CST
Subject: Anesthetic Tolerance

In general, tolerance to inhaled anesthetics does not occur.  In dogs, there is 
no tolerance after 500 minutes of exposure (1). This is also true in humans,
but 
the exposure time was shorter (2).  In mice, several days exposure to nitrous 
oxide (i.e. laughing gas) led to a small amount of tolerance (10-20% max) (3).  
So if narcosis operates like inhaled anesthetics, there is not evidence to 
suggest that tolerance will occur.

1. Eger, EI et al Anesthesiology 26:756-763, 1965.
2. Quasha, A. L. et al Anesthesiology 53:315-334, 1980
3. Smith R. A. et al Anesthesiology 50:505-509, 1979

Eddie Brian
eddie-brian@ui*.ed*

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