Sorry it took me a while to get you these but I hope that you enjoy them. The experiments that I did last week were very!!! promising. N2 inhibited and O2 stimulated the enzyme. The work was a bit rough and ready and I have to wait on some chemicals to arrive before I can do a complete time course and pressure study using O2, N2, air, and Helium. Watch this space. 1. Oury TD, Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity, Proc. Nat. Acad. of Sci. of the Unit. States of Amer. ,1992;89:9715-9719 2. Zhang J, Cererbral amino acids, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity, Brain Research 1993;606:56-62 These should get you started, I have a comprehensive literature search of topics relating to diving (if I every got it organised) so if you have any specific questions fire away. Gibbo John M. Gibbons 0171-793-1101 Home Univ. London School of Pharmacy 0171-582-6561 Fax Dept. of Pharmaceutical Chemistry 0171-753-5800 Wk ex 4882 jgibbo@cl*.ul*.ac*.uk* or jgibbo@cu*.ph*.lo*.ac*.uk*
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