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Hi Matthias

    Seems like a lot of people are interested, so I'll post the info here.
You can find diagrams of the circuit (and more information on the concept) on
the lab's web page at http://www.isocapnia.com/Non-Rebreathing.htm - as for
the German paper, I went back and looked in some bibliographies I have from
old papers, and the best I can find is the following:

Becker, H.F. et al, Effect of different levels of hyperoxia on breathing in
healthy subjects. JAP. 1996; 81/4:1683-1690

    I think that Becker actually references the German Paper of which I speak,
but it's been so long I can't remember exactly.

Hope this helps.

Ben




Matthias Voss wrote:

> Hello Ben,
> An interesting post, I would be interested , too, in further references.
> Btw, what did you do, add a small amount of CO2?
>
> Do you have any guess where and when this german paper was published ?
> I know some anaesthesiasts here who could help find it .
>
> Matthias
>
> Ben Greenhouse schrieb:
> >     I used to work in an Anaesthesia research lab, and we found in one
> > of our studies (and then looked hard and found it in an old German paper
> > who's author I can't remember) that patients would hyperventilate ever
> > so slightly when placed on pure oxygen.  We though it was an error in
> > our readings, perhaps due to different gas densities between oxygen and
> > air, so tried to back calibrate, but to no avail.  Then we found this
> > old paper that described this phenomenon.  Hyperventilation from pure O2
> > will cause a slight hypocapnia which will cause vasoconstriction.  We
> > developed a circuit that could keep this drop in CO2 from occuring
> > despite an increase in ventilation.  I can send references if either of
> > you are interested.

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