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irvine's spelling may be awful, but the gist of what he said is correct.

In certain persons there is a variant form of hemoglobin (HbS).
After releasing oxygen these HbS fibrils twist into helical rods and distort
and elongate the RedBloodCells
into a "sickle" shape. These "sickled" RBC can obstruct microcirculation
(clog capillaries).
symptoms: chronic anemia ; shortness of breath; fever; and episodic crises
that are characterized by severe pain in the abdomen, bones, or muscles.
(two pages of text roughly summarized to 4 sentences of standard english)

peterV



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