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Date: Mon, 12 Jun 2000 19:17:56 -0400 (EDT)
From: Michael Seeley <mseeley@po*.ne*>
To: techdiver@aquanaut.com
Subject: HEADACHES WHILE DIVING

God almighty you guys must bleed like 
hell if you ever cut yourself (ibuprofen prolongs bleeding time just 
like aspirin, not to mention the effects it has on your stomach). 


Just to set the record straight, aspirin and ibuprofen do NOT affect 
bleeding and platlets in the same way.  Below is a brief explaination
of the diference.  If anybody is really that interested I can send 
the whole article (with references).  Hopes this helps explain.
Thanks and Safe Diving
Mike Seeley


NON-STEROIDAL ANTIINFLAMMATORY AGENTS EFFECTS ON PLATELET FUNCTION
RESPONSE: 
Nonsteroidal antiinflammatory agents (NSAIAs) interfere with platelet 
aggregation and bleeding time due to inhibition of prostaglandin (PG) 
synthesis. NSAIAs inhibit cyclooxygenase, an enzyme that catalyzes 
synthesis of prostaglandins from arachadonic acid. The net result of 
this action is a reduction in thromboxane A2 production and release 
resulting in reduced platelet aggregation. Collagen-induced 
aggregation is inhibited by NSAIAs because this effect is dependent 
on thromboxane A2 formation (Schafer, 1995; Anon, 1979; Hirsh, 1979). 
Differences in the effect on platelet aggregation and bleeding time 
exist between aspirin and NSAIAs. Aspirin irreversibly inhibits 
platelet aggregation but NSAIAs reversibly inhibit platelet 
aggregation for the duration of the drug effect in the circulation. 
While aspirin increases the bleeding time by as much as two times the 
normal value, NSAIAs increase the bleeding time but it usually 
remains within the upper limit of normal (Schafer, 1995). 

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