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Date: Fri, 18 Feb 2000 10:07:48 -0800 (PST)
From: Esat Atikkan <atikkan@ya*.co*>
Subject: Re: Oxygen (the quick and dirty version)
To: techdiver@aquanaut.com


Having an MD publish a paper is not going to hack it!
U have ample proof of that.
As for the tenets of O2 toxicity.
Limiting disc to pulmonary O2 tox.  It is possible to
exceed, w/i reason, the 'safe pulmonary dose'
guidelines w/o out long term ill effects.  It is just
a matter of the amount of the discomfort one is
willing to put up w/.  (Paranthetically the jury is
out on the true long term effects - the carcinogenic
effects of free radicals).

It is also possible to change the threshold of the ill
effects of HBO or prolong the latent period w/
mediactions that scavenge free-radicals, the agents
currently held to B causal in oxtox.  Nutrients
additives have also been suggested.

As stated above it is thought tht it is the excessive
free radicals produced w/ HBO tht R the cause of the
pathogenesis.  The enzymes involved in scavenging,
like SOD, R considered induceable enzymes, meaning
that their titer increases as [substrate] increases. 
Though this may not reduce the [free radical], it will
tend to maintain a steady state, thus delaying overt
symptomalogy.

Still, it is also incontravertible that many if not
all divers, WKPP divers included, do report 'chest
burning' when exposed to protracted deco w/ high ppO2.

Maneouvers like air breaks do ameliorate this but do
not show up in the stnd OTU calculations wh/ require a
24 h break before the pulmonary clock is set to 0. 
Thus the calc values R artificially elevated relative
to actual expo values.


New data always becomes available.  The validity of
the data depends on not who publishes it but whether
it can B reproduced by an independent investigator.
Obviously all the details of the protocols used to
generate the data have to B made avialble for that to
happen.

Safe bubbles

Esat Atikkan


 

--- Mat Bloedorn <mbloedorn@ya*.co*> wrote:
> Michael,
> 
> You seem to think that everything there is to know
> about high PO2 has already been written and
> that there is nothing to be learned anymore.  You of
> all people should know this is never the
> case.
> 
> Who are you to say that what is currently know about
> O2 exposure is all there is to know?
> 
> Or are you saying that if the WKPP get an MD to
> publish a paper then their methods will be valid
> in your eyes?
> 
> Mat.
> 
> --- "Michael J. Black" <mjblackmd@ya*.co*> wrote:
> > The quick version:
> > 
> > Mr. Hunsucker says it's not OK to speed with your
> car (exceed
> > pO2 1.6), but it is OK to run stop signs (exceed
> 100% CNS clock, up
> > to 20,000%).
> > 
> > The dirty version:
> > 
> > Your account is seriously past due, please pay
> immediately (WKPP
> > divers are going to get hurt, and are lucky to
> have made it this far
> > if you listen to Mr. Hunsucker).
> > 
> > The safe version:
> > 
> > Do not speed or run stop signs.  Both can get you
> hurt.  MJB
> > __________________________________________________
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> > 
> 
> =====
> M-Plan - Free-Ware dive planning software utilizing
> Gradient Factors & the Buhlmann ZHL-16 algorithm at:
> mailto:mbloedorn@ya*.co*  
> http://www3.sympatico.ca/bloedorn
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