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Rich,

Yes, they are prescription drugs.  We have so far used them intravenously
during the hang (set up a closed system with minor amounts of heparin
and the drug, and at the start of deco we release a clamp and inject
the solution).

As to publication, Dick Vann has published some results on similiar
concept (ie, they used a continuous infusion of ISUPREL to vasodilate,
but this is also a very potent inotropic agent, so it is hard to 
differeniate between the effects of the vasodil. and the direct
increases in cardiac output due to the drug).  We have a very
small sample at this time, and probably will not be publishing
in the near future, but would really like to do some work with
more divers (try and get this past a human research committee).

Also, we are looking for a drug that has the same effects, but would
be useable via the subling. route.  Nifidepine has been suggested, but
it is a calcium channel blocker, and as such would/could have a direct
negative inotropic effect that I would prefer to avoid.

John
Submariner Research, Ltd.
(johncrea@de*.co*)

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