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Date: Tue, 24 Sep 1996 14:06:16 -1000 (HST)
From: Richard Pyle <deepreef@bi*.bi*.ha*.or*>
To: screwloose@ne*.co*
Cc: J Shepherd <jms@ta*.ed*.ac*.uk*>, techdiver@terra.net
Subject: Re: Larium anti-malaria and DCI

On Tue, 24 Sep 1996 screwloose@ne*.co* wrote:

> Doxycycline (a tetracycline) may also be used for malaria
> prophylaxis.Its mechanism of action is well known (inhibits protein
> synthesis) and as an antibiotic is probably not highly interactive
> with the CNS.

John Earle and I used doxycycline during our PNG trip (wheron I exposed 
myself to 64 hours of 1.4 PO2 in thirteen days, and John exposed 
himeself to 32 hours).  We were more than a little concerned about what 
effects the doxycycline would have viz. O2 toxicity, but we experienced 
no problems at all.  On the other hand, we have no way of knowing whether 
or not we were right on the edge of catastrophe.  With O2 toxicity, 
that's always the case.  Which is why George's ealier comment about how 
DCS can ruin your day but O2 toxicity can kill you should be taken to heart.

Aloha,
Rich

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