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From: J Shepherd <jms@ta*.ed*.ac*.uk*>
Subject: Re: Larium anti-malaria and DCI
To: gmiii@in*.co*
Cc: techdiver@terra.net
Date: Tue, 24 Sep 96 13:46:42 BST
> 
>  Marc, you do not find is interesteing that malaria and cycle cell come from
the 
> same region? Get serious , what do you think all of this is, happenstance? 
> 
	Define happenstance. The protection from malaria provided enough
selection pressure to maintain the presence of the sickle cell allele.
In the fens (UK) as well, oddly enough.

	Don't confuse intent with selection. Sickle cell may have
arisen everywhere. What is certain is that in the areas strongly
affected by malaria, it didn't get selected out.

	The mechanism (I think Marc is correct) is irrelevant.

	More relevant is the mode of action of the prophylactic in
question, for which we need the advice not of a geneticist, nor a
doctor, but a phamacologist. 

	Jason

	PS how did this start again?

	PPS loved the fib. seq. stuff. But I'm not wasting bandwidth to
say it. Hint.

> On Mon, 23 Sep 1996, "Marc Dufour" <emdx@ac*.ne*> wrote:
> >Le/On23 Sep 96 @ 18:51, vous ecrivites/you wrote:
> >
> >> 
> >>   Peter , speaking of malaria, is it not true that people with cycle
> >>   cell 
> >> predisposition are uneffected by malaria? Would that by any
> >> coincidence have to do with the fact that they come from the area
> >> wher the worst malaria exists (geneticly), and would  that not tell
> >> us something about the intent of the protection mechanisim. 
> >
> >It is not due to a protection mechanism, but rather because the 
> >microbe responsible for the propagation of malaria cannot survive in 
> >someone with sickle cell anemia.
> >
> >Is there a doctor in the audience?
> >
> >------------------ Pour la Republique Francaise du Quebec ------------------
> >     Canada: the only third world country that is a member of the G-7.
> >        ~~~ Last dive: a Boucherville island channel  - 8mfw ~~~
> >  This .sig is illegal in the states, because it contains a dirty word.
> > Marc Dufour - [\] ACUC6 31874 - TDI CD-0197 - http://www.accent.net/emdx 
> >--
> >Send mail for the `techdiver' mailing list to `techdiver@terra.net'.
> >Send subscription/archive requests to `techdiver-request@terra.net'.
> >
> >
> 
> George M. Irvine III
> DIR WKPP
> 1400 SE 11 ST Ft Lauderdale, FL 33316
> 954-493-6655 FAX 6698
> Email gmiiii@in*.co*
> 
> --
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