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An addendum to the previous message about complement _ "It is possible that tolerance to decompression is increased by repeated or a severe hyperbaric exposure (Rubenstein 1968; Walder 1968; Vann et.al. 1980; Daniels et al. 1984) and the exhaustion of bubble nuclei may explain this apparent acclimatization/adaptation. There may also be a biochemical explanation for this phenomenon. Bubbles activate complement in blood and serum in vitro (Ward et al. 1986; Shastri et al. 1991). The situation in vivo is less clear (Zhang et al. 1991), but the activation of complement appears to be correlated with the appearance of symptoms of deocmpression illness in rabbits (Ward et al. 1986, 1990) and man (Ward et al. 1987; Stevens et al. 1991). How this global phenomenon results in an isolated symptom such as pain in a limb has yet to be elucidated. However, acclimatization to repetitive dives could be due to the consumption or reduced activity of complement (Ward et al. 1990, 1991)." Bennett and Elliott, The Physiology and Medicine of Diving, 4th edition. John Submariner Research, Ltd. (johncrea@de*.co*)
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