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Subject: Re: Sudafed and DCS?
Date: Mon, 4 Mar 96 10:44:09 -0000
From: Robert Wolov <wolov@hi*.co*>
To: "Gerrit Conradie" <CONRADIE@fi*.su*.ac*.za*>, <techdiver@terra.net>

>Just wondering... was any work done on a possible connection between
>using pseudoephredine and DCS?  Reason for asking: me and a buddy got
>bent on separate occasions while using sudafed, admittedly, we also
>had 'marginally' unsafe profiles and probably deserved it.  Dropped
>the drugs after that.

I've not seen the reports myself (probably won't help anyway since I'm 
*not* a pharmacologist) but I believe there were reports by both DAN and 
the IAND (anecdotal).

Since decongestants and antihistamines indirectly work on the linings of 
blood vessel walls (the histamines directly effects the 
endothelium...inner lining of blood vessels) which impact of 
transmembrane exchanges, so reports of such associations are 
"believable". We don't know exact mechanisms yet (to the best of my 
knowledge) but I'm not "surprised" by such reports.

It would be nice if there were such formal studies in the dive community 
like there are in the aviation community. But, commercial pilots 
potentially could kill 200 people at a clip where divers drown alone, so 
I suppose there just is not the motivation.


Robb W

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