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To: techdive <techdiver@opal.com>
Subject: Re: CO2 transport in blood
From: Richard Pyle <deepreef@bi*.bi*.ha*.or*>
Date: Wed, 4 May 1994 11:07:15 +22305714 (HST)
On Tue, 3 May 1994, Frank Deutschmann wrote:

> Quite a while ago, I had built a small model of this exact gas
> transport problem, and we showed that at elevated pressure and
> workloads, several interesting things were possible:
> 1) Potential for Hypoxia
> 2) O2 DCS hits are possible (!)
> 3) O2 and CO2 may play a very large role in narcosis, possibly much
> greater than ever guessed.
> 4) O2 transport via plasma becomes important at elevated pressure
> 5) Buffer systems are heavily taxed at elevated pressures
> 6) Free radical production is increased at elevated pressures, and
> this likely brings on a whole set of other problems.
> 
> This work was never published, as I was/am primarily interested in the
> programming system I ues for building these types of models; this just
> happened to be an interesting model to explore.  Perhaps I will
> revisit it, in light of the (now much greater) interest.
> (Translation: No, I can't back up the points 1-6 above right now, so
> you can go ahead and ignore them.  But perhaps I'll come back and say
> "told you so." :-)

I, for one, would very much value any insight into these dynamics, whether
modeled or empirically tested.  I hope you do follow up when you get a chance!

Aloha,

Rich

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