------=_NextPart_001_0000_01C04A1A.B9D93980 Content-Type: text/plain; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable List: Does this not strike everyone as something of a (to quote my nephew) a DU= U_UH? Why not take an old - fasioned route: remove the allergen or dont d= ive. Congestion? Remove the dairy. Hay fever/ allergies? Go in for allerg= y analysis and resistance treatment. Mild Diabetes/hypo glycemia? Exercis= e and diet. I grew up in a family of medical professionals and watched th= em go from common sense "if it hurts dont do that" to manic pill pushers.= =20 Not a rant, just sometimes ya gotta wonder. My one and only real experien= ce being severely narced was after getting my butt up on my shoulders and= popping sudafed with coffee because "dammit I was going diving" even tho= my head felt like I could have busted rocks with it. I wonder how many o= ther accidents could be traced back to the old decongestant& coffee cure. dive safe y'all Brock ----- Original Message ----- From: screwloo@is*.ne* Sent: Wednesday, November 08, 2000 11:31 PM To: Barbara/San Francisco Cc: techdiver@aq*.co*; cavers@cavers.com; true@gu*.co* Subject: Re: Stroke alert 20 years overdue On Wed, 8 Nov 2000 14:34:16 -0800, you wrote: >...but better now than never. Ephedra is bad news. Phenylpropanolamine (= PPA, >used in OTC "weight loss" pills) and pseudoephedrine (Sudafed) deserve >similar consideration. All of these are CNS stimulants---they simulate >epinephrine's effects on vital organs, the CNS, and blood vessels. Heart >rate and blood pressure increase, as may anxiety. Divers who take them c= ould >well be more susceptible to underwater panic. And then there are drug/dr= ug >interactions, which can cause hypertension, changes in sensorium, and an= y >number of problems that are well known to the FDA but are not widely >publicized. It's PPA that's in the news lately.. there's serious statistical evidence that phenylpropanolamine can cause an increased risk of hemorrhages in women. It's a sympathomimetic.. a compound that mimics stimulants of the nervous system found naturally in the body. So is Pseudoephedrine (Sudafed). There may be useful parallels pertaining to PPA & Ephedra or Pseudafed Re: diving, just remember, caution is a GOOD thing >The bottom line: If you take a medication or, especially, a dietary >supplement, do your homework. The FDA approves medications based on >recommendations of physicians who work with the manufacturer and/or who >participate in clinical trials. More frightening are the unregulated dru= gs, >such as ephedra, ma huang, homeopathic remedies and botanicals. These >remedies usually are extracts of herbs, barks, or other plant substances= and >can have extremely potent effects. The consumer has no way of knowing wh= at >s/he's ingesting. Bottom line, the jury hasn't even plugged in the coffeepot.BUT!! there is some real evidence that any CNS stimulant should be contra-indicated in diving. PPA turns up in a MULTITUDE of OTC (Over-The-Counter) products. Many of the most popular cold remedies (Alka-Seltzer Cold Plus, Tavist D, Triaminic) contain PPA.. most of the rest contain pseuoephedrine..This is a no-brainer.. IF YOU'RE SICK> DON'T DIVE!!! Reality sucks, don't it? >Don't wait for a government agency or for anyone to warn you about these >issues. Ephedra should have been pulled from the market years ago. I pre= dict >that we'll see either 1) more of these "natural" substances being banned= by >FDA or 2) the pharmaceutical companies getting into the business of >"legitimizing" the so-called natural medications. The "snake oil" effect= and >profit potential create too lucrative a marketing opportunity to pass up= > >Best, >Barbara/San Francisco If they pull ephedra, they'll have to pull Starbuck's, too. and the PC's are ALREADY pressing the snake oil. I think we agree on 2 basic points 1) all decongestants are stimulants 2) divers should avoid stimulants while they're diving >----- Original Message ----- >From: "anthony rue" <true@gu*.co*> >To: <quest@gu*.co*> >Sent: Tuesday, November 07, 2000 7:37 AM >Subject: Stroke Alert (ephedra health risk) > > >> http://www.nejm.org/content/haller/1.asp >> >> Just released this morning, by The New England Journal of Medicine: >> >> Because of its potential public health implications, this article is b= eing >> released before its publication date. The final version of the report = will >> be published on December 21. >> >> Dietary supplements that contain ephedra alkaloids (sometimes called m= a >> huang) are widely promoted and used in the United States as a means of >> losing weight and increasing energy. In the light of recently reported >> adverse events related to use of these products, the Food and Drug >> Administration (FDA) has proposed limits on the dose and duration of u= se >of >> such supplements. The FDA requested an independent review of reports o= f >> adverse events related to the use of supplements that contained ephedr= a >> alkaloids to assess causation and to estimate the level of risk the us= e of >> these supplements poses to consumers. >> ... >> >> Ephedrine and related alkaloids have been associated with adverse >> cardiovascular events, including acute myocardial infarction, severe >> hypertension, myocarditis, and lethal cardiac arrhythmias. (10,11) >> Constriction of coronary arteries and, in some cases, vasospasm are >believed >> to be the mechanisms of myocarditis and myocardial infarction. The >> adrenergic effects of ephedrine shorten cardiac refractory periods, >> permitting the development of reentrant cardiac arrhythmias. Ephedrine= can >> predispose patients to both hemorrhagic and ischemic stroke. (12) >> Subarachnoid hemorrhage is thought to be a result of the hypertensive >action >> of ephedrine, which can be short lived, or of cerebral vasculitis, whi= ch >has >> been described in association with a variety of sympathomimetic drugs. >> (13,14) Thrombotic stroke is presumably related to vasoconstriction of >large >> cerebral arteries, which leads to local thrombosis as a result of stas= is >and >> sympathomimetic-induced platelet activation. >> >> Because of the severity of the adverse events that we reviewed and, in >> particular, the occurrence of events that caused permanent disability = and >> death, we conclude that dietary supplements that contain ephedra alkal= oids >> pose a serious health risk to some users. Although the incidence of >serious >> adverse effects cannot be determined from our analysis, our findings >arouse >> concern about the risks of these products, given that they have no >> scientifically established benefits. Our findings indicate the need fo= r a >> better understanding of the determinants of individual susceptibility = to >the >> serious adverse effects of dietary supplements containing ephedra >alkaloids >> so that appropriate dosing guidelines and warnings can be devised. >> >> >> --------------------------------------------------------------------- >> To unsubscribe, e-mail: quest-unsubscribe@gu*.co* >> For additional commands, e-mail: quest-help@gu*.co* >>___________________________________________________________ Get more from your time online. FREE MSN Explorer download : http://expl= orer.msn.com ------=_NextPart_001_0000_01C04A1A.B9D93980 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable <HTML><BODY STYLE=3D"font:10pt verdana; border:none;"><DIV><BR></DIV> <DI= V>List:</DIV> <DIV><BR>Does this not strike everyone as something of a (t= o quote my nephew) a DUU_UH? Why not take an old - fasioned route: remove= the allergen or dont dive. Congestion? Remove the dairy. Hay fever/ alle= rgies? Go in for allergy analysis and resistance treatment. Mil= d Diabetes/hypo glycemia? Exercise and diet. I grew up in a family of med= ical professionals and watched them go from common sense "if it hurts don= t do that" to manic pill pushers. </DIV> <DIV> </DIV> <DIV>Not a ran= t, just sometimes ya gotta wonder. My one and only real experience being = severely narced was after getting my butt up on my shoulders and popping = sudafed with coffee because "dammit I was going diving" even tho my head = felt like I could have busted rocks with it. I wonder how many other acci= dents could be traced back to the old decongestant& coffee cure.</DIV= > <DIV> </DIV> <DIV>dive safe y'all</DIV> <DIV>Brock</DIV> <DIV>&nbs= p;</DIV> <BLOCKQUOTE style=3D"BORDER-LEFT: #000000 2px solid; MARGIN-LEFT= : 5px; MARGIN-RIGHT: 0px; PADDING-LEFT: 5px; PADDING-RIGHT: 0px"> <DIV st= yle=3D"FONT: 10pt Arial">----- Original Message -----</DIV> <DIV style=3D= "BACKGROUND: #e4e4e4; FONT: 10pt Arial; FONT-COLOR: black"><B>From:</B>&n= bsp;screwloo@is*.ne*</DIV> <DIV style=3D"FONT: 10pt Arial"><B>Sent:</= B> Wednesday, November 08, 2000 11:31 PM</DIV> <DIV style=3D"FONT: 1= 0pt Arial"><B>To:</B> Barbara/San Francisco</DIV> <DIV style=3D"FONT= : 10pt Arial"><B>Cc:</B> techdiver@aq*.co*; cavers@cavers.com; = true@gu*.co*</DIV> <DIV style=3D"FONT: 10pt Arial"><B>Subject:</B> R= e: Stroke alert 20 years overdue</DIV> <DIV><BR></DIV>On Wed, 8 Nov 2000 = 14:34:16 -0800, you wrote:<BR><BR>>...but better now than never. Ephed= ra is bad news. Phenylpropanolamine (PPA,<BR>>used in OTC "weight loss= " pills) and pseudoephedrine (Sudafed) deserve<BR>>similar considerati= on. All of these are CNS stimulants---they simulate<BR>>epinephrine's = effects on vital organs, the CNS, and blood vessels. Heart<BR>>rate an= d blood pressure increase, as may anxiety. Divers who take them could<BR>= >well be more susceptible to underwater panic. And then there are drug= /drug<BR>>interactions, which can cause hypertension, changes in senso= rium, and any<BR>>number of problems that are well known to the FDA bu= t are not widely<BR>>publicized.<BR><BR>It's PPA that's in the news la= tely.. there's serious statistical<BR>evidence that phenylpropanolamine c= an cause an increased risk of<BR>hemorrhages in women. It's a sympa= thomimetic.. a compound that mimics<BR>stimulants of the nervous system f= ound naturally in the body. So is<BR>Pseudoephedrine (Sudafed). There may= be useful parallels pertaining to<BR>PPA & Ephedra or Pseudafed Re: = diving, just remember, caution is a<BR>GOOD thing<BR><BR><BR>>The bott= om line: If you take a medication or, especially, a dietary<BR>>supple= ment, do your homework. The FDA approves medications based on<BR>>reco= mmendations of physicians who work with the manufacturer and/or who<BR>&g= t;participate in clinical trials. More frightening are the unregulated dr= ugs,<BR>>such as ephedra, ma huang, homeopathic remedies and botanical= s. These<BR>>remedies usually are extracts of herbs, barks, or other p= lant substances and<BR>>can have extremely potent effects. The consume= r has no way of knowing what<BR>>s/he's ingesting.<BR><BR>Bottom line,= the jury hasn't even plugged in the coffeepot.BUT!! there<BR>is some rea= l evidence that any CNS stimulant should be<BR>contra-indicated in diving= <BR> PPA turns up in a MULTITUDE of OTC (Over-The-Counter) p= roducts.<BR>Many of the most popular cold remedies (Alka-Seltzer Cold Plu= s, Tavist<BR>D, Triaminic) contain PPA.. most of the rest contain<BR>pseu= oephedrine..This is a no-brainer..<BR> IF YOU'RE = SICK> DON'T DIVE!!!<BR>Reality sucks, don't it?<BR><BR>>Don't wait = for a government agency or for anyone to warn you about these<BR>>issu= es. Ephedra should have been pulled from the market years ago. I predict<= BR>>that we'll see either 1) more of these "natural" substances being = banned by<BR>>FDA or 2) the pharmaceutical companies getting int= o the business of<BR>>"legitimizing" the so-called natural medications= The "snake oil" effect and<BR>>profit potential create too lucrative= a marketing opportunity to pass up.<BR>><BR>>Best,<BR>>Barbara/= San Francisco<BR><BR>If they pull ephedra, they'll have to pull Starbuck'= s, too. and the<BR>PC's are ALREADY pressing the snake oil.<BR> I t= hink we agree on 2 basic points<BR>1) all decongestants are stimulants<BR= >2) divers should avoid stimulants while they're diving<BR><BR><BR>>--= --- Original Message -----<BR>>From: "anthony rue" <true@gu*.co*>= ;<BR>>To: <quest@gu*.co*><BR>>Sent: Tuesday, November 07, 200= 0 7:37 AM<BR>>Subject: Stroke Alert (ephedra health risk)<BR>><BR>&= gt;<BR>>> http://www.nejm.org/content/haller/1.asp<BR>>><BR>&= gt;> Just released this morning, by The New England Journal of Medicin= e:<BR>>><BR>>> Because of its potential public health implica= tions, this article is being<BR>>> released before its publication = date. The final version of the report will<BR>>> be published on De= cember 21.<BR>>><BR>>> Dietary supplements that contain ephed= ra alkaloids (sometimes called ma<BR>>> huang) are widely promoted = and used in the United States as a means of<BR>>> losing weight and= increasing energy. In the light of recently reported<BR>>> adverse= events related to use of these products, the Food and Drug<BR>>> A= dministration (FDA) has proposed limits on the dose and duration of use<B= R>>of<BR>>> such supplements. The FDA requested an independent r= eview of reports of<BR>>> adverse events related to the use of supp= lements that contained ephedra<BR>>> alkaloids to assess causation = and to estimate the level of risk the use of<BR>>> these supplement= s poses to consumers.<BR>>> ...<BR>>><BR>>> Ephedrine a= nd related alkaloids have been associated with adverse<BR>>> cardio= vascular events, including acute myocardial infarction, severe<BR>>>= ; hypertension, myocarditis, and lethal cardiac arrhythmias. (10,11)<BR>&= gt;> Constriction of coronary arteries and, in some cases, vasospasm a= re<BR>>believed<BR>>> to be the mechanisms of myocarditis and my= ocardial infarction. The<BR>>> adrenergic effects of ephedrine shor= ten cardiac refractory periods,<BR>>> permitting the development of= reentrant cardiac arrhythmias. Ephedrine can<BR>>> predispose pati= ents to both hemorrhagic and ischemic stroke. (12)<BR>>> Subarachno= id hemorrhage is thought to be a result of the hypertensive<BR>>action= <BR>>> of ephedrine, which can be short lived, or of cerebral vascu= litis, which<BR>>has<BR>>> been described in association with a = variety of sympathomimetic drugs.<BR>>> (13,14) Thrombotic stroke i= s presumably related to vasoconstriction of<BR>>large<BR>>> cere= bral arteries, which leads to local thrombosis as a result of stasis<BR>&= gt;and<BR>>> sympathomimetic-induced platelet activation.<BR>>&g= t;<BR>>> Because of the severity of the adverse events that we revi= ewed and, in<BR>>> particular, the occurrence of events that caused= permanent disability and<BR>>> death, we conclude that dietary sup= plements that contain ephedra alkaloids<BR>>> pose a serious health= risk to some users. Although the incidence of<BR>>serious<BR>>>= adverse effects cannot be determined from our analysis, our findings<BR>= >arouse<BR>>> concern about the risks of these products, given t= hat they have no<BR>>> scientifically established benefits. Our fin= dings indicate the need for a<BR>>> better understanding of the det= erminants of individual susceptibility to<BR>>the<BR>>> serious = adverse effects of dietary supplements containing ephedra<BR>>alkaloid= s<BR>>> so that appropriate dosing guidelines and warnings can be d= evised.<BR>>><BR>>><BR>>> -----------------------------= ----------------------------------------<BR>>> To unsubscribe, e-ma= il: quest-unsubscribe@gu*.co*<BR>>> For additional commands, e-mail= : quest-help@gu*.co*<BR>>><BR><BR><BR> <DIV></DIV></BLOCKQUOTE></BO= DY></HTML><DIV><BR>____________________________________________________ __= _____<BR>Get more from your time online. FREE MSN Explorer download : ht= tp://explorer.msn.com</DIV> ------=_NextPart_001_0000_01C04A1A.B9D93980--
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